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Elevated blood glucose concentrations are central to diabetic complication pathogenesis. Regulating postprandial hyperglycemia through reduced intestinal glucose absorption represents a key therapeutic strategy for type 2 diabetes. Conventional treatments often present challenges of cost and side effects, prompting interest in natural alternatives. Watermelon rind contains bioactive compounds with documented antioxidant, antihypertensive, antitumor, and antimicrobial properties. This study evaluated the hypoglycemic effects of watermelon rind water extracts—infusion (IF) and decoction (DC)—in normal mice with sucrose loading. The methodology involved oral administration of IF and DC extracts (833.3 mg/kg) or acarbose (standard drug), followed by sucrose loading (4 g/kg) via oral gavage after 30 minutes. Blood glucose measurements were taken at 0-, 15-, 30-, 60-, 90-, and 120-min post-loading. Results demonstrated that both IF and DC extracts significantly reduced blood glucose levels (p<0.05) compared to sucrose control, with effects comparable to acarbose. These findings indicate that watermelon rind water extract shows considerable promise as a potential therapeutic agent for diabetes management, offering a natural alternative to conventional pharmacological interventions.

Decoction; Infusion; Sucrose; Watermelon