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Ascorbic acid (vitamin C) is widely recognized for its role in supporting immune function and its potential in protecting against COVID-19 infection. Consequently, global consumption of ascorbic acid-containing health supplements has increased, including in Indonesia, especially during the COVID-19 pandemic. This study aimed to compare the analytical accuracy of two commonly used methods, i.e. iodimetric titration and colorimetric analysis, for determining ascorbic acid concentrations in health supplement of 1000 mg ascorbic acid. Both methods leverage ascorbic acid’s reducing properties, which will reduce iodine in iodimetric titration and 2,6-dichloroiondophenol in colorimetric analysis. The results demonstrated that iodimetric titration yielded concentration range between 98.11% and 101.57%, while the colorimetric method produced values ranging from 96.75% to 99,75%. All results complied with the Indonesian Pharmacopoeia standards, which require active substance levels to be within 90.0% to 110.0% of the labeled amount. The findings indicate the iodimetric titration offers accuracy comparable to the colorimetric method and is a reliable alternative for routine quality control of ascorbic acid in health supplements.

Accuracy; Indonesian Pharmacopoeia; Reducing agent