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Tablets are solid dosage forms containing active ingredients with or without additional excipients. In manufacturing, a binder is required to produce compact tablets that do not break easily. One commonly used binder is gelatin. Wet granulation is one of the tablet manufacturing methods that requires a drying stage with precise temperature and duration settings to obtain tablets of good quality. This study uses two different levels to analyze the effect of granule drying temperature and time on the characteristics of paracetamol tablets. The research method used is a pure experimental design with two factors and two levels of treatment. Data were analyzed using the Shapiro-Wilk normality test with a criterion of p > 0.05. Normally distributed data were further analyzed using the Design Expert 13 (Free Trial) application to determine the optimal formulation. The results showed that drying temperature and time significantly affected the physical characteristics of paracetamol granules and tablets. Increasing the temperature and drying time led to decreased moisture content, powder flow, angle of repose, compressibility, increased tablet hardness, tablet friability, and disintegration time. Based on the analysis, the optimal temperature range for paracetamol granule preparation was 40-60°C, with a drying duration of 3-6 hours.

Paracetamol tablet; wet granulation; gelatin binder; drying temperature; drying time