Salbutamol sulfate is a bronchodilator used to treat asthma, but existing dosage forms have limitations. This study aimed to develop a Fast Dissolving Sublingual Film (FDSF) for improved delivery. Using a factorial design, the optimal FDSF formulation was identified as a combination of 300 mg pectin and 10 mg CMC Na. This combination exhibited rapid disintegration (4.67 ± 1.02 seconds) and high folding endurance (725.33 ± 4.73 folds). The FDSF demonstrated excellent drug release, with 95.19 ± 1.30% of salbutamol sulfate released within 60 seconds. These results suggest that the developed FDSF has the potential to offer a convenient and effective alternative for asthma treatment.