The immune system plays a crucial role in defending the body against pathogens. Herbal-based immunomodulators have gained increasing interest due to their natural origin and potential to provide broad immunological benefits. Turmeric (Curcuma xanthorrhiza) has been extensively studied for its immunostimulant properties, with a focus on produced IL-β therapies in macrophage cells. Turmeric has low solubility, hence the latest breakthrough in turmeric preparations is the SNEDDS. This research aims to assess the impact of turmeric-loaded SNEDDS on the immune response by measuring IL- β cytokine production in RAW 264.7 cells. Turmeric-loaded SNEDDS was formulated using a high-energy method. The IL- β cytokine production evaluated using ELISA assay kits. The characterization test of SNEDDS briefly shows a transmittance value (99.75% ± 0.07), a particle size (84.7 nm ± 0.071), a polydispersity index (0.485 ± 0.173), and a zeta potential (-33.47 mV ± 0.060), indicating that the sample is nano-sized and stable. The IL- β production in SNEDDS at 100 µg/mL concentration is 0.754 ± 0.007, surpassing the cell control value of 0.250 ± 0.059. The result indicates that the sample can enhance IL- β secretion in RAW 264.7 cells. The turmeric-loaded SNEDDS was stable and increased production of IL- β.