Background: Hypertension required a good handling because it could lead to complications such as kidney failure, heart failure, and stroke. According to the WHO in 2023, approximately 1.28 billion adults aged 30-79 years worldwide are living with hypertension with two-thirds residing in low-and middle-income countries. Various herbs can be used as an alternative for treat hypertension because it is more safer. Some of them were a roselle, chayote, and aloe vera. Objectives: This study was conducted to examine the antihypertensive potential of four combination of extracts of roselle flower petals, chayote fruits, and aloe vera leaves. Methodology: Twenty-four Sprague Dawley rats divided in six groups; negative control, positive control and 4 test groups with mixture of a roselle, chayote, and aloe vera extract at dose of 1 (120:500:200), 2 (120:1000:200), 3(240:500:200) and 4(240:1000:200) mg/kg BW respectively. Negative control group induced with adrenaline at dose of 1.2 µg/kg i.p and positive control gives captopril 0.45 mg/kg BW p.o with non-invasive blood pressure methods. Results: The blood pressure of dose 1, 3 and 4 has a significant difference to the negative control, and did not have a significant difference to the positive control.  Brief conclusion: Dose 3 showed the best potential with average decrease systole and diastole value are 18.31% and 23.19% respectively.