The red betel plant is a medicinal plant that can be used for treatment purposes. The part of the red betel plant (Piper crocatum Ruiz & Pav.) that can be utilized is the stem. The aim of this study was to determine the compound content in the stem of red betel and whether it contains the same compounds as found in the red betel leaves. Qualitative identification was conducted using histochemical tests and phytochemical screening, which included tube tests and Thin Layer Chromatography (TLC). The histochemical test was performed to detect the presence of alkaloids, flavonoids, and tannins, followed by tube testing with the addition of specific reagents. The extraction of red betel stems was carried out using the maceration method with 96% ethanol as the solvent. The identification of the quercetin compound in the red betel stem extract was conducted using the TLC method with two different mobile phases: toluene:ethyl acetate:formic acid (7:2.5:0.5) and chloroform:ethyl acetate (9:1). The results from the histochemical and tube-based phytochemical screening showed that the red betel stem tested positive for alkaloids, flavonoids, and tannins. In the TLC phytochemical screening with the toluene:ethyl acetate:formic acid (7:2.5:0.5) mobile phase, the Rf value of quercetin was 0.3, while the Rf values obtained from the 96% ethanol extract of red betel stem were 0.28, 0.28, and 0.29, with spot colors differing from those of the quercetin reference compound. Meanwhile, in TLC with the chloroform:ethyl acetate (9:1) mobile phase, the quercetin reference compound was not eluted.