This study aims to determine the effect of liquidity, solvency, and profitability ratios on company performance as measured by the return of pharmaceutical sector stocks in Indonesia and listed on the Indonesia Stock Exchange for the 2021-2023 period. The sample in this study is pharmaceutical sector companies listed on the Indonesia Stock Exchange in 2021-2023 and include their financial statements on the Indonesia Stock Exchange in 2021-2023. The companies are Darya-Varia Laboratoria Tbk, Kalbe Farma Tbk, PT Pyridam Farma Tbk, PT Industri Jamu Dan Farmasi Sido Muncul Tbk, PT Soho Global Health Tbk, and Tempo Scan Pacific Tbk. The methods used in this study include quantitative methods and multiple linear regression analysis. The implications of this study show that the liquidity ratio with the current ratio, solvency ratio with Debt to Asset Ratio (DAR), and profitability ratio with return on assets (ROA) have an influence on the performance condition of pharmaceutical sector companies listed on the Indonesia Stock Exchange for the 2021-2023 period. That way, liquidity, solvency, and profitability ratios have a significant effect on the performance of pharmaceutical sector companies listed on the Indonesia Stock Exchange 2021-2023.