This study uses a bibliometric literature review method to elaborate on eco enzymes, blue economy, and sustainable river ecosystems. The purpose of this study is to map research on the relationship between eco enzymes and clean and healthy river ecosystems for sustainable economic growth during the period 2019 – 2023 using the Scopus database. The results showed that there was a fluctuation in the number of publications, where the end of the observation period showed an upward trend. The network visualization identified four main research clusters: red, green, yellow, and blue. The red cluster focuses on aspects of policy, governance, and broader ecosystem considerations.  The green cluster focuses on the immediate benefits of sustainable development. The yellow cluster focuses on global aspects and sustainable development policies. Meanwhile, the blue cluster focuses on the knowledge base or literature related to the sustainable blue economy. This finding provides valuable insights for the government and the community in waste management to achieve the Blue Gold Economy.