This study focuses on analyzing the determining factors of particulate matter (PM_2.5) air pollution in provinces on the island of Java. Air pollution is a phenomenon of environmental damage that continues to occur in line with human activities which have an impact on humans themselves, including health, global warming, and climate change. PM_2.5 particulate matter pollution parameters were chosen because these micro particles easily enter through inhalation and pose a big risk to human health. Quantitative research methods were employed to make sense of the available secondary data. Econometric models-Panel Data Regression Analysis are used to examine the sources causing air pollution-PM_2.5. The results show that population density and manufacturing industrial production are important factors in increasing air pollution-PM_2.5. This can be explained by the fact that population density creates complexity in handling garbage and household waste which has the potential to increase emissions, while the manufacturing industry is associated with industrial waste and factory chimney smoke which directly pollutes the air. Therefore, controlling sources of emissions and disturbances is needed to prevent a decrease in air quality caused by these two sectors.